Bottle to Throttle rule is a rule for pilots to consume alcohol before flights normally is 8 hours, however most of the airlines will increase it to 12 hours for a better time margin. This rule basically is based on the metabolism rate for a normal human to eliminate pure alcohol with a certain rate. A hangover effect should be over for a normal people after 8 hours after consumed certain amount of alcohol.
For my personal kind advice, don't drink alcohol before drive as well as before flight.
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